Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort

BackgroundAllergic disorders are the consequence of IgE sensitization to allergens. Population studies have shown that certain human leukocyte antigen (HLA) alleles associated with increased or decreased risk developing allergy.ObjectiveWe aimed characterize relationship between HLA class II allelic diversity and in an understudied Arab population.MethodsWe explored associations 7 allergen mixes mesquite (comprising 41 food aeroallergens) 45 common classical a well-defined cohort 797 individuals representing general adult population Qatari nationals long-term residents. To do so, we performed calling from whole genome sequencing data at 2-field resolution using 2 independent algorithms. We then applied 3 different regression models assess either each mix independently, context other allergens tested, polysensitization.ResultsMore than half (n = 447) study participants showed least 1 allergen, most them 400) aeroallergens (Phadiatop). identified statistically significant negative positive 24 alleles. These been reported confer protection variety diseases; however, only few previously allergy populations.ConclusionsOur reveals several new protective genetic markers for allergen-specific sensitization. This is first essential step toward better understanding origins allergic diseases this population. Allergic allergy. polysensitization. More populations. Our